Bully surgeons have nowhere to hide now, top doctor says: "After detailing cases of physical abuse in operating theatres and female trainees being propositioned for sex in return for tutoring, the final report recommended the College set up mentoring and coaching for surgeons that need to change their behaviour.
Commenting on this recommendation, Mr Campbell said surgeons who had been misbehaving should expect to get pulled up because bystanders were being encouraged to show leadership.
"Bystanders have been silent for too long. We want people to be tapped on the shoulder. If it's done at a relatively early stage and it's just some bad jokes, we'd want it to be dealt with relatively informally in an educational way," he said, adding that many of the accused would likely be good people who need only education.
But Mr Campbell warned that serious offenders would be referred to the police, the Medical Board of Australia, or an equal opportunity commission. He said the College was continuing to run its complaints line that connects callers to a college counsellor, not a fellow surgeon. Former federal discrimination commissioner Susan Halliday has been appointed to independently review the College's management of complaints every six months.
The expert advisory group's damning report on discrimination, bullying and sexual harassment in surgery said the problems were rife in the profession. A survey of 3500 people found about half of surgeons, trainees and international graduates had suffered some form of abuse.
Women and people new to the profession bore the brunt of it - 54 per cent of surgical trainees said they had recently been bullied, compared with 31 per cent of surgeons with more than a decade of experience. Six out of 10 women said they had been bullied and three in 10 said they had been sexually harassed.
One woman told of how she would be considered for a job only if she had her "tubes tied". A man who stood up for his female colleagues said that he then been singled out for ill treatment, while other respondents spoke of being kicked under the table during operations. International graduates reported being ganged up on or threatened.
The expert advisory group, which was chaired by former Victorian health minister Rob Knowles AO, said hospitals, governments and others health sector organisations had to work on the problem. The College has committed to publishing an action plan in November.
"The College has shown courage and commitment in establishing the EAG (expert advisory group) and in accepting in full the findings and recommendations of the draft report," Mr Knowles said. "
'via Blog this'
Tuesday, September 29, 2015
Thursday, September 24, 2015
Psychiatrist Alex Sharah, who compared lesbians to paedophiles, disqualified
Psychiatrist Alex Sharah, who compared lesbians to paedophiles, disqualified: "Psychiatrist Alexander Anthony Sharah, 80, has been disqualified from registering as a medical practitioner after inappropriate treatment of patients, having also compared lesbians to paedophiles, because both "don't know that they are doing something wrong so we still have to love them".
In a decision handed down on Wednesday, the Civil and Administrative Tribunal rebuked Mr Sharah – a former candidate for the Christian Democratic Party – for encouraging his patients to explore religion to ease their mental health problems.
The decision said: "More than one of the patients referred to the displays of religious objects and material in his waiting room and consulting room, something which, in our view, is clearly inappropriate.
"[Mr Sharah] was indifferent, we consider, to whether patients might find unwelcome and confronting references to the power of prayer, religious beliefs and gestures that had religious symbolism, such as clasping hands and presenting crucifixes."
Mr Sharah is also a "figurehead" in the Men's Justice Movement, which believes the Family Court favours women over men after marriage breakdowns."
http://www.smh.com.au/nsw/psychiatrist-alex-sharah-who-compared-lesbians-to-paedophiles-disqualified-20150923-gjt969.html
(moderator: was he not disqualified because he failed in treating his patients? rubbing 'holy water' on someone's forehead is not an accepted treatment, at least I was not able to find any clinical trials in any of the peer reviewed journals. This one example proves the power medical professionals have. There is little doubt that the 80 (!) year old psychiatrist has been doing this kind of 'treatment' most of his working life. Is this the first time he is challenged (and disqualified for 2 years...)?
In a decision handed down on Wednesday, the Civil and Administrative Tribunal rebuked Mr Sharah – a former candidate for the Christian Democratic Party – for encouraging his patients to explore religion to ease their mental health problems.
The decision said: "More than one of the patients referred to the displays of religious objects and material in his waiting room and consulting room, something which, in our view, is clearly inappropriate.
"[Mr Sharah] was indifferent, we consider, to whether patients might find unwelcome and confronting references to the power of prayer, religious beliefs and gestures that had religious symbolism, such as clasping hands and presenting crucifixes."
Mr Sharah is also a "figurehead" in the Men's Justice Movement, which believes the Family Court favours women over men after marriage breakdowns."
http://www.smh.com.au/nsw/psychiatrist-alex-sharah-who-compared-lesbians-to-paedophiles-disqualified-20150923-gjt969.html
(moderator: was he not disqualified because he failed in treating his patients? rubbing 'holy water' on someone's forehead is not an accepted treatment, at least I was not able to find any clinical trials in any of the peer reviewed journals. This one example proves the power medical professionals have. There is little doubt that the 80 (!) year old psychiatrist has been doing this kind of 'treatment' most of his working life. Is this the first time he is challenged (and disqualified for 2 years...)?
Tuesday, September 22, 2015
Anti-depressant paroxetine linked to youth suicide and no more effective than a placebo, researchers find - ABC News (Australian Broadcasting Corporation)
Anti-depressant paroxetine linked to youth suicide and no more effective than a placebo, researchers find - ABC News (Australian Broadcasting Corporation):
'via Blog this'
'via Blog this'
Sunday, September 20, 2015
Approved anti-depressant deemed unsafe
Approved anti-depressant deemed unsafe:
Studies suggest that patients, clinicians, and society often hold unrealistic expectations about the effectiveness of tests and treatments. Two articles in this issue add to that literature. In New Zealand, Hudson et al3 surveyed 977 primary care patients and found that many overestimated the benefits of cancer screening and chemopreventive medications. The minimum benefit from screening that respondents deemed acceptable was less than their known benefit. The survey had a modest sample size and low response rate (36%), and its findings might not be fully applicable to other countries, but US studies have reported a similar problem. For example, a variety of studies document Americans' appetite for procedures of dubious effectiveness and their overestimation of benefits.4,5
Physicians are not immune to false beliefs about clinical efficacy or complication rates.8Correcting such misperceptions has always been part of the impetus for the evidence-based medicine movement and its promulgation of systematic evidence reviews, practice guidelines, and other tools that present the facts on benefits, safety, and scientific uncertainties. Even these tools, however, can reflect the misconceptions of those who produce them. The specialists who serve on expert panels derive much of their clinical case knowledge from the patients with advanced disease who fill their clinics. Having seen the worst of the worst, they are less sympathetic to expressions of concern about the potential harms of interventions or imperfections in efficacy studies.9Whereas epidemiologists consider the population denominator to put the numerator in perspective, the world of specialists is confined to the numerator, giving them a skewed basis for judging the population prevalence of diseases or benefit-risk ratios. Were this not enough, the preeminent scientists who often serve on guideline panels bring additional biases, such as being the authors of key studies under review or having financial ties to industry.10
http://www.annfammed.org/content/10/6/491.full
Studies suggest that patients, clinicians, and society often hold unrealistic expectations about the effectiveness of tests and treatments. Two articles in this issue add to that literature. In New Zealand, Hudson et al3 surveyed 977 primary care patients and found that many overestimated the benefits of cancer screening and chemopreventive medications. The minimum benefit from screening that respondents deemed acceptable was less than their known benefit. The survey had a modest sample size and low response rate (36%), and its findings might not be fully applicable to other countries, but US studies have reported a similar problem. For example, a variety of studies document Americans' appetite for procedures of dubious effectiveness and their overestimation of benefits.4,5
Physicians are not immune to false beliefs about clinical efficacy or complication rates.8Correcting such misperceptions has always been part of the impetus for the evidence-based medicine movement and its promulgation of systematic evidence reviews, practice guidelines, and other tools that present the facts on benefits, safety, and scientific uncertainties. Even these tools, however, can reflect the misconceptions of those who produce them. The specialists who serve on expert panels derive much of their clinical case knowledge from the patients with advanced disease who fill their clinics. Having seen the worst of the worst, they are less sympathetic to expressions of concern about the potential harms of interventions or imperfections in efficacy studies.9Whereas epidemiologists consider the population denominator to put the numerator in perspective, the world of specialists is confined to the numerator, giving them a skewed basis for judging the population prevalence of diseases or benefit-risk ratios. Were this not enough, the preeminent scientists who often serve on guideline panels bring additional biases, such as being the authors of key studies under review or having financial ties to industry.10
http://www.annfammed.org/content/10/6/491.full
Friday, September 18, 2015
Baker IDI Melbourne fabricated research results
“Fabricated results” retract JAMA clinical trial, plus a sub-analysis of the data - Retraction Watch at Retraction Watch: "“Fabricated results” retract JAMA clinical trial, plus a sub-analysis of the data
with 2 comments
A JAMA clinical trial that suggested a blood pressure drug could help patients increase their physical fitness, and a sub-analysis of those data, have been retracted after “an admission of fabricated results” by the first author on both papers.
The three-year clinical trial was published in JAMA in 2013. It was retracted this morning.
The trial found ramipril helped patients with artery disease walk longer and with less pain, according to the abstract:
Among patients with intermittent claudication, 24-week treatment with ramipril resulted in significant increases in pain-free and maximum treadmill walking times compared with placebo. This was associated with a significant increase in the physical functioning component of the SF-36 score.
The retraction note explains how the fabricated data came to light: "
with 2 comments
A JAMA clinical trial that suggested a blood pressure drug could help patients increase their physical fitness, and a sub-analysis of those data, have been retracted after “an admission of fabricated results” by the first author on both papers.
The three-year clinical trial was published in JAMA in 2013. It was retracted this morning.
The trial found ramipril helped patients with artery disease walk longer and with less pain, according to the abstract:
Among patients with intermittent claudication, 24-week treatment with ramipril resulted in significant increases in pain-free and maximum treadmill walking times compared with placebo. This was associated with a significant increase in the physical functioning component of the SF-36 score.
The retraction note explains how the fabricated data came to light: "
Saturday, September 12, 2015
"for any inappropriate care to occur, complicit action on a large scale is required" - MJA
Med J Aust 2015;; 203 (4): 161-162.: "Instead of dismissing, we should consider that for any inappropriate care to occur, complicit action on a large scale is required. To deliver a do-not-do procedure a medical practitioner must first be credentialled, have a defined scope of practice and operate within their clinical team alongside support services and the governance structures of an organisation. Start counting how many people are involved. Therefore, the question we should be asking is: how is it possible for inappropriate care to occur? And what systems-level agreements perpetuate this situation?"https://www.mja.com.au/.../it-not-appropriate-dismiss...
and:
"Far too many patients in some Australian hospitals get a treatment they should not receive, against all evidence that the treatment is unnecessary or does not work.
This report identifies five treatments that should not be given to certain types of patients. Yet this happened to nearly 6000 people – or 16 people a day – in 2010-11." http://grattan.edu.au/.../questionable-care-avoiding.../
"the Royal Australasian College of Surgeons has discovered its ranks are riddled with bullies, creeps and bigots"
"Royal Australasian College of Surgeons revelations: Patients complicit in promoting surgeons' God complex" - you see? it's your fault if you are mistreated or abused by your surgeon...
"Yet the Royal Australasian College of Surgeons has discovered its ranks are riddled with bullies, creeps and bigots."
Read more: http://www.smh.com.au/…/royal-australasian-college-of-surge…
Follow us: @smh on Twitter | sydneymorningherald on Facebook
or archived page:
https://archive.is/AYnuj
Follow us: @smh on Twitter | sydneymorningherald on Facebook
or archived page:
https://archive.is/AYnuj
Saturday, August 15, 2015
Doctor Skeptic: Fixing a hole
Doctor Skeptic: Fixing a hole: Migraine is common, affecting millions of people worldwide. A patent foramen ovale (PFO – a ‘hole in the heart’ that lets blood cross from...
Tuesday, December 23, 2014
This study of hype in press releases will change journalism | Science News
This study of hype in press releases will change journalism | Science News: "The most important thing to remember is that there are people, and sometimes patients, waiting on the end of the news cycle. “I wouldn’t be doing [healthnewsreviews.org] if I didn’t think that these kinds of messages and misleading conclusions and observations and statements made in many news releases have the potential — and indeed I think that potential is realized — of hurting people at the end of the food chain,” Schwitzer says. Everyone in the news cycle bears responsibility, in the end, for getting it right."
'via Blog this'
'via Blog this'
Exaggeration in health science news releases - exaggerations communicated by reporters are frequently already present in press releases put out by academic institutions
Exaggeration in health science news releases & what we're going to do about it: "“For me, the takeaway from this study is that there are multiple messengers to blame when it comes to exaggeration in health care news stories. As we’ve shown at HealthNewsReview.org, journalists often need to do a better job of vetting scientific research in their stories. But according to these results, the exaggerations communicated by reporters are frequently already present in press releases put out by academic institutions. This suggests that press officers who write the releases, and the researchers who collaborate on them, are also key players when it comes to the promotion of misinformation.
The study authors make a great point, which is that if academic institutions are the ones initiating the introduction of misleading claims, then there’s a tremendous opportunity for them to improve the quality of health care news if they can change their ways. I think our new effort to review news releases will help with that transition, because it provides a level of accountability that’s been missing until now. I’m really excited to see that our instincts about the need for this service are being emphatically confirmed by these results.”"
'via Blog this'
The study authors make a great point, which is that if academic institutions are the ones initiating the introduction of misleading claims, then there’s a tremendous opportunity for them to improve the quality of health care news if they can change their ways. I think our new effort to review news releases will help with that transition, because it provides a level of accountability that’s been missing until now. I’m really excited to see that our instincts about the need for this service are being emphatically confirmed by these results.”"
'via Blog this'
Thursday, December 4, 2014
Evidence based medicine is broken | The BMJ
"How many people care that the research pond is polluted,5 with fraud, sham diagnosis, short term data, poor regulation, surrogate ends, questionnaires that can’t be validated, and statistically significant but clinically irrelevant outcomes? Medical experts who should be providing oversight are on the take. Even the National Institute for Health and Care Excellence and the Cochrane Collaboration do not exclude authors with conflicts of interest, who therefore have predetermined agendas.6 7 The current incarnation of EBM is corrupted, let down by academics and regulators alike.8"
http://www.bmj.com/content/348/bmj.g22
http://www.bmj.com/content/348/bmj.g22
Saturday, November 29, 2014
"the standards for the evidence are often low and tainted by commercial or personal interests"
In the eyes of doctors and the public, evidence-based medicine is the gold standard of clinic practice. If it’s based on evidence from trials and laboratories, it must be right.
However, evidence-based medicine has its critics, as a bilious outbreak of comment and letters in the BMJ demonstrated recently. Early last month a Glasgow GP, Des Spence, said that the system of EBM had been corrupted. “If we don’t tackle the flaws of EBM there will be a disaster, but I fear it will take a disaster before anyone will listen,” he wrote.
How could anyone fault the notion of treatment based on scientifically validated evidence? No one. But the critics of EBM argue heatedly that the standards for the evidence are often low and tainted by commercial or personal interests. Dr Spence accuses drug companies of
manipulating the gold standard to their own benefit. “Today EBM is a loaded gun at clinicians’ heads. ‘You better do as the evidence says,’ it hisses, leaving no room for discretion or judgment. EBM is now the problem, fueling overdiagnosis and overtreatment.”
A number of letters pointed out that, while EBM had its flaws, doctors still need to exercise their clinical judgement. They write the prescriptions, not the drug companies.
Dr Spence was supported by Dr Miran Epstein, a medical ethicist at The London School of Medicine. He writes that “EBM “does not regard polluted information, whether it involves misconduct or not, as a sufficient condition for rendering disclosure inadequate. Thus, it lets informed consent degenerate into a legal fiction and the principle of autonomy into a cynical farce. Worst of all, it is perfectly ethical: being the codified expression of the collective conscience of our medicine, it naturally purports to be moral.”
manipulating the gold standard to their own benefit. “Today EBM is a loaded gun at clinicians’ heads. ‘You better do as the evidence says,’ it hisses, leaving no room for discretion or judgment. EBM is now the problem, fueling overdiagnosis and overtreatment.”
A number of letters pointed out that, while EBM had its flaws, doctors still need to exercise their clinical judgement. They write the prescriptions, not the drug companies.
Dr Spence was supported by Dr Miran Epstein, a medical ethicist at The London School of Medicine. He writes that “EBM “does not regard polluted information, whether it involves misconduct or not, as a sufficient condition for rendering disclosure inadequate. Thus, it lets informed consent degenerate into a legal fiction and the principle of autonomy into a cynical farce. Worst of all, it is perfectly ethical: being the codified expression of the collective conscience of our medicine, it naturally purports to be moral.”
And he was supported by lawyer and ethicist Charles Foster, writing in the Practical Ethics blog. He believes that the editors of journals need the help of a regulator to sift the wheat from the chaff. “Journals can’t do it all. We need a cynical, skeptical, well-funded, well-staffed and ideologically very left-wing regulator. With huge teeth.”
Evidence-based medicine comes under attack
by Michael Cook | 8 Feb 2014 |
tags: commercialization, evidence-based medicine
http://www.bioedge.org/index.php/bioethics/bioethics_article/10841
by Michael Cook | 8 Feb 2014 |
tags: commercialization, evidence-based medicine
http://www.bioedge.org/index.php/bioethics/bioethics_article/10841
Thursday, November 27, 2014
Publication bias distorting evidence base, systematic reviews and clinical guidelines
For decades, the systematic review of published randomised controlled trials has been considered the gold standard in medical research, and this was what the original Cochrane reviewers did.
By combining data from all published trials on a particular subject, researchers are able to see effects in much larger numbers of people than would typically be included in a single trial, in theory making their conclusions more powerful.
In theory. The problem in reality is a small thing called publication bias.
Some trials are simply more likely to be published than others, potentially skewing the results of this kind of meta-analysis.
MJA InSIght, Monday, 14 October, 2013
Jane McCredie: Sharing evidence
Monday, November 3, 2014
"pharma giant used fictitious patient quotes to promote its fluticasone product"
"GLAXOSMITHKLINE is among three companies to be fined for breaches of Medicines Australia’s Code of Conduct after the pharma giant used fictitious patient quotes to promote its fluticasone product, Seretide.
MA said in its July–September quarterly report that the Code of Conduct committee dealt with allegations by Mundipharma that GSK’s promotional material on Seretide was false and misleading.
The committee said that while publishing fictitious patient quotes is itself a breach of the code, GSK had exacerbated its breach by placing the statements in quote marks beside the image of a young woman.
“GSK had agreed during intercompany dialogue to make clear that the statements were not from real patients,” the committee said."
The committee said that while publishing fictitious patient quotes is itself a breach of the code, GSK had exacerbated its breach by placing the statements in quote marks beside the image of a young woman.
“GSK had agreed during intercompany dialogue to make clear that the statements were not from real patients,” the committee said."
Medical Observer,
False claims: Pharma companies fined
Warwick Stanley 3rd Nov 2014
Thursday, August 7, 2014
“In no other area than Sympathetic Surgery, disagreement, conflicting opinion, different definitions and misleading interpretations of the data exist"
8th ISSS Symposium New York, 2009:
“In no other area than Sympathetic Surgery, disagreement, conflicting opinion, different definitions and misleading interpretations of the data exist. Mainly regarding surgical indications, the level and extent of the procedure and results evaluation”.
ATS Expert Consensus for the Surgical Treatment of Hyperhidrosis powerpoint presentation – October 6, 2012, XVI Congreso Boliviana de Cirugia Cardiaca, Toracica y Vascular, Santa Cruz de la Sierra, Bolivia.
http://cirugiadetorax.org/2012/10/09/vats-sympathectomy-for-hyperhidrosis-dr-jose-ribas-de-milanez-de-campos/
or:
https://archive.today/Q047q
Thursday, July 3, 2014
medical procedures are misrepresented in the media
"If your patients rely on the mainstream media for medical advice, they may well think that cancer has been cured many times over, and have other inflated views about the benefits of new treatments and tests.
AND they probably would be shocked to learn about the potential downsides of many medical interventions, let alone costs.
That’s the conclusion of a comprehensive analysis of almost 2000 medical news items published in the US by print, online and television outlets between 2006 and 2013.
It was undertaken by the media watchdog Health News Review, and recently published in JAMA Internal Medicine (5 May, 2014). Most stories were judged unsatisfactory in how they covered the costs, benefits, harms and quality of the evidence supporting the new treatment or test, and how it was compared to alternatives.
“Drugs, medical devices, and other interventions were usually portrayed positively; potential harms were minimised and costs were ignored,” wrote the founder of Health News Review, Gary Schwitzer."
Melissa Sweet, Medical Observer, 24th Jun 2014
Tuesday, June 24, 2014
Lies, Damned Lies, and Medical Science
http://www.theatlantic.com/magazine/archive/2010/11/lies-damned-lies-and-medical-science/8269/
Much of what medical researchers conclude in their studies is misleading, exaggerated, or flat-out wrong. So why are doctors—to a striking extent—still drawing upon misinformation in their everyday practice? Dr. John Ioannidis has spent his career challenging his peers by exposing their bad science. By David H. Freedman"
https://archive.today/bSQNG
Much of what medical researchers conclude in their studies is misleading, exaggerated, or flat-out wrong. So why are doctors—to a striking extent—still drawing upon misinformation in their everyday practice? Dr. John Ioannidis has spent his career challenging his peers by exposing their bad science. By David H. Freedman"
https://archive.today/bSQNG
Monday, June 16, 2014
Pharma marketing impacts on junior doctor prescribing
JAMA Network | JAMA Internal Medicine | Association of Marketing Interactions With Medical Trainees’ Knowledge About Evidence-Based Prescribing: Results From a National Survey: "A 10-point higher industry relations index was associated with 15% lower odds of selecting an evidence-based prescribing choice (odds ratio [OR], 0.85; 95% CI, 0.79-0.92) (P < .001). There was also a significant association between the industry relations index and greater odds of choosing to prescribe brand-name drugs (OR, 1.08; 95% CI, 1.00-1.16) (P = .04).
Conclusions and Relevance Among physician trainees, our survey showed an association between positive attitudes toward industry-physician interactions and less knowledge about evidence-based prescribing and greater inclination to recommend brand-name drugs. Policies intended to insulate trainees from pharmaceutical marketing may promote better educational outcomes."
Conclusions and Relevance Among physician trainees, our survey showed an association between positive attitudes toward industry-physician interactions and less knowledge about evidence-based prescribing and greater inclination to recommend brand-name drugs. Policies intended to insulate trainees from pharmaceutical marketing may promote better educational outcomes."
Thursday, June 5, 2014
most of the existing literature is geared towards assessing only the effectiveness of the surgical sympathectomy
"Given the fact that most of the existing literature is geared towards a) assessing only the effectiveness of the surgical sympathectomy procedures, and b) publishing only studies with positive results, adverse effects and complications are not systematically reported but rather as a secondary outcome. It seems, therefore, highly likely that the complications as reported here, are truly underestimated.
The study indicates that surgical sympathectomy, irrespective of operative approach and indication, may be associated with many and potentially serious complications."
Are We Paying a High Price for Surgical Sympathectomy? A Systematic Literature Review of Late Complications
http://www.jpain.org/article/S1526-5900%2800%2944124-6/abstract
The study indicates that surgical sympathectomy, irrespective of operative approach and indication, may be associated with many and potentially serious complications."
Are We Paying a High Price for Surgical Sympathectomy? A Systematic Literature Review of Late Complications
http://www.jpain.org/article/S1526-5900%2800%2944124-6/abstract
Friday, April 11, 2014
Antiviral drug stockpile a waste of money, says study | smh.com.au
Antiviral drug stockpile a waste of money, says study | smh.com.au: "Governments around the globe may have wasted billions of dollars stockpiling antiviral drugs to use against an influenza pandemic, according to a damning review drawing on previously suppressed data.
Australia was one of several countries to stockpile the drugs known as Tamiflu and Relenza, believing they would reduce hospital admissions and complications of influenza, such as pneumonia, in the event of an outbreak of swine or bird flu.
But a review of data from trials involving more than 24,000 people, published on Thursday by the Cochrane Collaboration and the British Medical Journal, concluded the drugs were of only marginal benefit, shortening the duration of influenza symptoms by just half a day.
The review found no good evidence that the drugs prevented the spread of the virus between people, or any of its serious consequences, such as infections. It found Tamiflu increased the risk of psychiatric disturbances, renal problems, nausea, vomiting and headaches."
'via Blog this'
Australia was one of several countries to stockpile the drugs known as Tamiflu and Relenza, believing they would reduce hospital admissions and complications of influenza, such as pneumonia, in the event of an outbreak of swine or bird flu.
But a review of data from trials involving more than 24,000 people, published on Thursday by the Cochrane Collaboration and the British Medical Journal, concluded the drugs were of only marginal benefit, shortening the duration of influenza symptoms by just half a day.
The review found no good evidence that the drugs prevented the spread of the virus between people, or any of its serious consequences, such as infections. It found Tamiflu increased the risk of psychiatric disturbances, renal problems, nausea, vomiting and headaches."
'via Blog this'
Monday, February 24, 2014
US scientists were “accomplices after the fact” in Japanese doctors’ war crimes
BioEdge: US scientists were “accomplices after the fact” in Japanese doctors’ war crimes: "A fascinating answer appears in the Cambridge Quarterly of Healthcare Ethics. The broad outline of the story has been well documented, even if it is not widely known. To cut a long story short, the Americans struck a deal with the doctors. They traded immunity from prosecution for access to scientific information from the ghastly Japanese experiments – many of which are too grim to detail here. (If you have the stomach for it, a remorseful doctor describes, at the age of 90, some of his vivisection experiments in an article in the Japan Times.)
A report from US scientists who interviewed the staff of Unit 731 and the surviving records concluded that “Such information could not be obtained in our own laboratories because of scruples [sic] attached to human experimentation"
'via Blog this'
A report from US scientists who interviewed the staff of Unit 731 and the surviving records concluded that “Such information could not be obtained in our own laboratories because of scruples [sic] attached to human experimentation"
'via Blog this'
Monday, February 10, 2014
BioEdge: The scandal of wasted research dollars
BioEdge: The scandal of wasted research dollars: "Twenty years ago, a British statistician complained in the BMJ that much medical research was “seriously flawed through the use of inappropriate designs, unrepresentative samples, small samples, incorrect methods of analysis, and faulty interpretation.”
Today, says the BMJ’s former editor, the influential writer Richard Smith, the only word to be changed in that diagnosis is probably “much”. It should now be “most”. And he complains that the leaders of the medical profession are not interested in changing the situation."
'via Blog this'
Today, says the BMJ’s former editor, the influential writer Richard Smith, the only word to be changed in that diagnosis is probably “much”. It should now be “most”. And he complains that the leaders of the medical profession are not interested in changing the situation."
'via Blog this'
Evidence based medicine is broken - BMJ
Des Spence cites “poor regulation” as one of the phenomena that compound the profit-driven pollution of Evidence-Based Medicine (EBM).[1] He is not alone. This conception seems to be gaining in popularity.[2,3]
Indeed, the current regulation is handmaiden to the polluters, as this partial list of examples indicates:
• The regulation does not demand that the research agenda be driven strictly by patient needs, not corporate interests.
• It is silent about the adequacy of selection criteria, outcome measures, and statistical significance, three variables that are often used by the polluters to manipulate evidence.
• It says nothing about what should count as scientific and unscientific research. This lacuna allows the latter to take place too, provided, of course, that it labels itself as "scientific".
• The regulation introduces exceptions to the head-to-head rule, exceptions that allow the polluters to test every new drug against placebo or no treatment thereby showing us exactly what they want: efficacy, but not necessarily over the current treatment.[4]
• It does not ban regulators, health care institutions and medical professionals from having financial conflicts of interest. Worse than that, "transparency", the only thing it insists on and quite feebly so, gives both the doctor and the patient nothing but the misleading impression that they can make a truly informed choice.
• The regulation does not ban subject recruitment through financial incentives, a practice capable of introducing outcome bias.
• It does not ban seeding trials, i.e., marketing exercises concealed as scientific research.
• It does not ban manipulative advertising to both doctor and patient inside or outside "scientific" journals.
• It does not ban medicalisation and “me too” drugs.
• It does not regard polluted information, whether it involves misconduct or not, as a sufficient condition for rendering disclosure inadequate. Thus, it lets informed consent degenerate into a legal fiction and the principle of autonomy into a cynical farce.[5]
• Worst of all, it is perfectly ethical: being the codified expression of the collective conscience of our medicine, it naturally purports to be moral.
• It is silent about the adequacy of selection criteria, outcome measures, and statistical significance, three variables that are often used by the polluters to manipulate evidence.
• It says nothing about what should count as scientific and unscientific research. This lacuna allows the latter to take place too, provided, of course, that it labels itself as "scientific".
• The regulation introduces exceptions to the head-to-head rule, exceptions that allow the polluters to test every new drug against placebo or no treatment thereby showing us exactly what they want: efficacy, but not necessarily over the current treatment.[4]
• It does not ban regulators, health care institutions and medical professionals from having financial conflicts of interest. Worse than that, "transparency", the only thing it insists on and quite feebly so, gives both the doctor and the patient nothing but the misleading impression that they can make a truly informed choice.
• The regulation does not ban subject recruitment through financial incentives, a practice capable of introducing outcome bias.
• It does not ban seeding trials, i.e., marketing exercises concealed as scientific research.
• It does not ban manipulative advertising to both doctor and patient inside or outside "scientific" journals.
• It does not ban medicalisation and “me too” drugs.
• It does not regard polluted information, whether it involves misconduct or not, as a sufficient condition for rendering disclosure inadequate. Thus, it lets informed consent degenerate into a legal fiction and the principle of autonomy into a cynical farce.[5]
• Worst of all, it is perfectly ethical: being the codified expression of the collective conscience of our medicine, it naturally purports to be moral.
In light of these examples we should ask ourselves: If the polluters of medical knowledge can tick the ethical box, then what does that say about our ethic?
Having said that, the notion of poor ethic-regulation can be both misleading and self-defeating if it is taken to entail that an ethical-regulatory change could help purify EBM. This is not only false. It actually plays to the hands of the polluters.
The belief that there must be some truly humanistic ethic-regulation out there that could help purify EBM is totally absurd. As long as our medicine depends financially on and must buy its tools from the polluters — in short, as long as it remains under their thumb — it will reject such an ethic-regulation wholesale or, more dangerously, co-opt it to suit their interests. There can be no other option. If we wish to have a truly humanistic ethic, we should get ourselves a truly humanistic medicine first.
1 Spence D. Evidence based medicine is broken. BMJ 2014;348:g22.
2 Goldacre B. Bad Pharma. London:Fourth Estate, 2012.
3 Gøtzsche PC. Deadly Medicines and Organised Crime: How big pharma has corrupted healthcare. London:Redcliffe, 2013.
4 WMA Declaration of Helsinki 2013; pt. 33.
5 Epstein M. Legal and institutional fictions in medical ethics: a common, and yet largely overlooked, phenomenon. J Med Ethics 2007;33(6):362-364.
http://www.bmj.com/content/348/bmj.g22/rr/680463
BioEdge: Evidence-based medicine comes under attack
BioEdge: Evidence-based medicine comes under attack: "evidence-based medicine has its critics, as a bilious outbreak of comment and letters in the BMJ demonstrated recently. Early last month a Glasgow GP, Des Spence, said that the system of EBM had been corrupted. “If we don’t tackle the flaws of EBM there will be a disaster, but I fear it will take a disaster before anyone will listen,” he wrote.
How could anyone fault the notion of treatment based on scientifically validated evidence? No one. But the critics of EBM argue heatedly that the standards for the evidence are often low and tainted by commercial or personal interests."
http://www.bioedge.org/index.php/bioethics/bioethics_article/10841
How could anyone fault the notion of treatment based on scientifically validated evidence? No one. But the critics of EBM argue heatedly that the standards for the evidence are often low and tainted by commercial or personal interests."
http://www.bioedge.org/index.php/bioethics/bioethics_article/10841
Sunday, January 26, 2014
Does removing breast cancer affect survival?
Allow me to make an assertion: breast cancer survival is not influenced by surgical excision of the primary tumour. This goes against the prevailing wisdom that cancer is cured by removing it, but that kind of thinking is simplistic and at odds with much of the evidence. Lets walk through that evidence.
There is a theory that breast cancer is a systemic, rather than a local disease, and that local control (by surgery) does not influence the course of the disease regarding its ability to cause death. The common thinking about breast cancer is that it starts in the breast and spreads such that if you remove it early, and completely, you can be cured. This is the basis of breast cancer screening, but as I have discussed before, there is debate about whether screening reduces one’s risk of dying.
more:
http://doctorskeptic.blogspot.com.au/2014/01/does-removing-breast-cancer-affect.html
Friday, November 15, 2013
Health experts with pharma links more likely to talk up risk
"A number of scientists on the World Health Organization’s (WHO) flu advisory committee, which monitors pandemics and provides guidance for governments, for example, have disclosed links with the pharmaceutical industry.
But given that the media can influence demand for pharmaceutical products and perceptions of risk, we set out to examine whether health experts commentating on swine flu more generally were also more likely to have links to drug companies.
Analysing UK newspaper coverage of the swine flu pandemic between April and July 2009 – the period in which the UK government was taking decisions on how best to respond to the emerging pandemic, including providing the public with vaccine and antiviral drugs – we looked for how often scientists were quoted in articles on the pandemic from a wide range of publications.
We then looked at these comments in more detail to see if scientists made an assessment of the risk to the public from swine flu, and if so, we compared these against assessments made by official agencies such as the Department of Health."
"We found that half of the health experts that commentated on the use of antiviral drugs or vaccine had competing interests. And scientists promoting the use of antiviral drugs were eight times more likely to have a competing interest than those that didn’t comment on their use. We also found that health experts with competing interests were six times more likely than those without to predict a higher risk to the public compared to official assessments."
https://theconversation.com/health-experts-with-pharma-links-more-likely-to-talk-up-risk-20108
Friday, November 8, 2013
Is sympathectomy safe and effective?
Well, it depends on who you ask.
We already know what the surgeons who offer the surgery have to say about it, as most of us was conned into having the surgery. We also know what these surgeons have to say about non-surgical options (ineffective, tedious, time-consuming, expensive, not permanent, resulting in disabling side-effects, very painful, useless - on one website patients are told that application of BOTOX requires general anaesthesia, just to scare them off that one... : http://archive.is/lSWd0 ). The question is answered very differently when you ask a medical professional who offers these non-surgical treatment options. Their advice and their version of FACTS always depends on the treatment and technique they have on offer.
A very simple exercise: print out the texts from few of these websites and offer it to someone to read. Then let them guess what they think which treatment the medical professional is siding with, that is: which treatment is being offered and advertised by them.
Here is a sample. You will most certainly detect that this medical professional is NOT offering ETS, as he selected different FACTS about the procedure and it's results.
and because you can never be safe enough, here is the archived version:
Thursday, November 7, 2013
Making all clinical data public is vital for better medical care
Making all clinical data public is vital for better medical care: "An article published in the journal of the British Medical Association, BMJ, earlier this week illustrates a devastating problem with the “evidence base” in the academic medical literature.
A large proportion of drug trials, particularly those sponsored by pharmaceutical companies, never get published, skewing our picture of drugs' effectiveness and safety."
'via Blog this'
A large proportion of drug trials, particularly those sponsored by pharmaceutical companies, never get published, skewing our picture of drugs' effectiveness and safety."
'via Blog this'
Any sensible person or scientist knows that the drug laws are not based on the science of drugs
David Nutt: 'I was sacked, I was angry, I was right': "Any sensible person or scientist knows that the drug laws are not based on the science of drugs. And it’s a collusion among scientists, politicians, and to some extent the public, to ignore that. It is anti-establishment, but also not, in that it’s such an obvious thing. It’s like the emperor’s new clothes – someone needed to speak up."
'via Blog this'
'via Blog this'
Medical Students Examine Unconscious Patients Without Consent | Fox News
Medical Students Examine Unconscious Patients Without Consent | Fox News: "Australian and UK medical students carried out intrusive procedures on unconscious and anesthetized patients without first gaining consent, news.com.au reported Friday.
The unauthorized examinations included genital, rectal and breast exams, according to Australian women's magazine Madison, and raised serious questions about the ethics of future doctors.
The research, to be published in international medical journal Medical Education, describes -- among others -- a student with "no qualms" about performing an anal examination on a female patient because she did not think the woman's consent was relevant.
Another case is of a man who was subjected to rectal examinations from a "queue" of medical students after he was anesthetized for surgery.
The author of the study, Professor Charlotte Rees, voiced concerns about senior medical staff ordering students to perform unauthorized procedures, leaving the students torn between the strong ethics of consent in society and the weak ethics of some medical staff."
'via Blog this'
The unauthorized examinations included genital, rectal and breast exams, according to Australian women's magazine Madison, and raised serious questions about the ethics of future doctors.
The research, to be published in international medical journal Medical Education, describes -- among others -- a student with "no qualms" about performing an anal examination on a female patient because she did not think the woman's consent was relevant.
Another case is of a man who was subjected to rectal examinations from a "queue" of medical students after he was anesthetized for surgery.
The author of the study, Professor Charlotte Rees, voiced concerns about senior medical staff ordering students to perform unauthorized procedures, leaving the students torn between the strong ethics of consent in society and the weak ethics of some medical staff."
'via Blog this'
Epidemiology of medical error | BMJ
Epidemiology of medical error | BMJ: "The Harvard and Australian studies into medical error remain the only studies that provide population level data on the rates of injuries to patients in hospitals and they identified a substantial amount of medical error
In the United States medical error results in 44 000–98 000 unnecessary deaths each year and 1 000 000 excess injuries"
'via Blog this'
In the United States medical error results in 44 000–98 000 unnecessary deaths each year and 1 000 000 excess injuries"
'via Blog this'
Wednesday, November 6, 2013
Pharma giant fined billions for fraud
GLOBAL healthcare giant Johnson & Johnson will pay more than $2.3 billion to settle allegations that it fraudulently promoted drugs and used kickbacks to promote sales.
In one of the largest healthcare fraud settlements in US history, J&J's criminal and civil fine covers allegations the company marketed risperidone (Risperdal) and other prescription drugs for uses not approved as safe and effective by the Food and Drug Administration (FDA).
The settlement further covers kickbacks J&J allegedly paid to physicians and pharmacies for prescribing and promoting those drugs, the US Justice Department said yesterday.
The settlement further covers kickbacks J&J allegedly paid to physicians and pharmacies for prescribing and promoting those drugs, the US Justice Department said yesterday.
Medical Observer
5tov 2013
Monday, November 4, 2013
MORE than 25% of large randomised clinical trials registered with ClinicalTrials.gov have not published any results
MORE than 25% of large randomised clinical trials registered with ClinicalTrials.gov have not published any results in medical literature or in the registry database, according to research published in the BMJ. The researchers examined 585 registered trials with at least 500 participants and which had been completed by 2009. They found 171 trials with a total of almost 300 000 participants had not been published. Industry-sponsored trials were the most likely to remain unpublished. Of unpublished trials, 78% had no results available in ClinicalTrials.gov. For trials where the recruitment status was listed as “completed”, 26% (132/513) remained unpublished, and 29 trials were described as “active, not recruiting”; with 10 of these unpublished. The BMJ authors said trial investigators and sponsors had an ethical obligation to study participants to publish trial results. “The lack of availability of results from these trials contributes to publication bias and also constitutes a failure to honor the ethical contract that is the basis for exposing study participants to the risks inherent in trial participation”, they wrote. “Additional safeguards are needed to ensure timely public dissemination of trial data.”
http://www.bmj.com/content/347/bmj.f6104
Sunday, November 3, 2013
Scientists voice fears over ethics of drug trials remaining unpublished
http://www.theguardian.com/science/2013/oct/29/scientists-fears-over-unpublished-drug-trials
"It is amazing how long an operation can ‘linger’ after it has been shown to be ineffective"
The 1959 sham surgery experiment (link) involved surgery on all of the participants, but half of them didn’t actually have the artery ligated, and the patients were ‘blinded’ to the type of treatment they received. Most patients in both groups felt better (in fact all patients in the study had improved exercise tolerance), but they were no more likely to improve if they had the surgery than if they had the sham surgery, showing that the treatment did not have a specific therapeutic effect, only a perceived effect. Basically, the operation didn’t work. The study was small (17 enrolled) which might make you think that it was not a powerful enough study to detect the advantage of surgery, but I can counter that with the observation that the patients in the placebo group actually did better than the (real) surgical group for most outcomes. A larger study may have been more conclusive about a difference between the groups: it might have been able to show us that the surgery was significantly harmful.
The good news is that the operation fell out of favour after publication of this study. Similar results from trials of knee arthroscopy for arthritis (link) have not resulted in a similar decrease in rates of surgery (definitely not in my country, anyway). It is amazing how long an operation can ‘linger’ after it has been shown to be ineffective (see my blog on blood letting here). We need to rely more on what the science tells us than on our gut feelings.
http://doctorskeptic.blogspot.com.au/2012/07/placebo-surgery-1-surgery-for-angina.html
Tuesday, October 8, 2013
List of predatory publishers:
http://scholarlyoa.com/2012/12/06/bealls-list-of-predatory-publishers-2013/
Sunday, October 6, 2013
corruption is the greatest moral challenge facing medicine today
Bioethical debate tends to focus on controversial medical procedures, such as genetic modification, IVF, euthanasia and abortion. The latest issue of the Indian Journal of Medical Ethics questions this, arguing that corruption is the greatest moral challenge facing medicine today.
In the lead article, Dr Subrata Chattopadhyay asserts that, "undermining the moral vision -- and nobility -- of the art of healing, corruption is arguably the most serious ethical crisis in medicine today". Chattopadhyay says that corruption in medicine is common everywhere, though he focuses his home country of India.The corruption of disgraced former WMA president Ketan Desai is, it seems, indicative of endemic misconduct.
Other articles in the issue include a summary of corruption cases in several of the major pharmaceutical companies of Europe and the US and the declining ethical standards of the Indian Medical Council.
Monday, September 30, 2013
THE risk of fever in children after one dose of trivalent influenza vaccine could be more than three times higher than published data suggests
"THE risk of fever in children after one dose of trivalent influenza vaccine (TIV) could be more than three times higher than published data suggests, according to new research."
"Australian researchers sought to assess the baseline prevalence of fever following the 2010 ban on CSL’s Fluvax in children under five but the information was not available in English language journals."
"The review found that following one dose of TIV, the median average weekly risk of any fever (≥37.5 degrees Celsius) was 26% in unpublished trials compared to 8.2% in published papers."
Medical Observer,
Neil Bramwell, 30th Sept 2013
Saturday, September 21, 2013
Unravelling madness
Richard Bentall believes that patients should be given the choice to have drug treatment, rather than be coerced into it. Photo / Simon Baker
In 1993 Richard Bentall went a bit mad.
He voluntarily took an antipsychotic drug and at first thought he'd get through unscathed.
"For the first hour I didn't feel too bad. I thought maybe this is okay. I can get away with this. I felt a bit light-headed."
Then somebody asked him to fill in a form. "I looked at this test and I couldn't have filled it in to save my life. It would have been easier to climb Mt Everest."
That was the least of his troubles. Bentall, an expert on psychosis from the University of Bangor in Wales who is in New Zealand under the University of Auckland Hood Fellowship programme, developed akathisia - unpleasant sensations of inner restlessness and an inability to sit still.
"It was accompanied by a feeling that I couldn't do anything, which is really distressing. I felt profoundly depressed. They tried to persuade me to do these cognitive tests on the computer and I just started crying."
Volunteers were given either 5mg of the antipsychotic droperidol, 1mg of lorazepam, a type of tranquillizer, or a placebo.
"The experiment completely failed," says Bentall. "Because first, it's absolutely mind-bogglingly obvious to anybody after an hour whether or not they are taking an antipsychotic or a placebo - the side effects are so marked. There is no such thing as a placebo antipsychotic in that sense."
But it was the fact that most of the healthy volunteers who took the antipsychotic became so unwell, let alone do the cognitive tests, that meant the study couldn't continue. One psychiatrist became suicidal and had to be put under observation.
In his controversial book Let Them Eat Prozac Healy wrote about what the volunteers experienced. "It was not like anything that had happened to them before... Highly personal memories of previous unhappy times - broken relationships or loneliness - seemed to be flooding back. And if they previously held themselves responsible for these unhappy times, they seemed to hold themselves responsible for feeling the way they did now as well."
Story of antipsychotics is one of myth and misrepresentation
The way antipsychotics have been misrepresented, their benefits inflated, their dangers minimised, illustrates how what is presented as neutral and objective “science” may in fact conceal a whole array of political and commercial interests. The psychiatric profession wanted to present a new image to society and politicians wished to replace costly mental institutions with cheaper community care.
All of this has helped transform antipsychotic drugs from dreaded chemical straight-jackets to modern-day soothers, lining the coffers of the pharmaceutical industry along the way. It’s time we woke up.
"Serious effects have been obscured because the frank descriptions provided by early clinicians were replaced by a vision of the drugs as a cleverly targeted, sophisticated and essentially benign treatment. And despite no convincing evidence to support the theory, the view emerged that they work by reversing an underlying “chemical imbalance” or other such abnormality rather than by inducing an abnormal or altered state."
Friday, September 20, 2013
Neuralgia due to sympathectomy common
Depending on the skill of the surgeon and difficulty encountered performing various intraoperative maneuvers, the incidence of complications following sympathectomy should be the same as that following any other extraperitoneal or extrapleural operation. However, a frequent complication following sympathectomy, and one which is apparently unrelated to operative technique, is that of postsympathectomy neuralgia.
This neuralgia is characterized by aching thigh pain after lumbar sympathectomy or aching shoulder and arm pain after cervical sympathectomy. The pain is intense in severity, sudden in onset and disappearance, and not related to any major neurologic manifestations.
Recently we have reviewed the files of the Vascular Surgical Service at the West Roxbury Veteran's Hospital and the literature on this condition. This report is a presentation of our findings.
Incidence Pain following sympathectomy has been described as "an all too common complaint."8 Reports have varied in incidence from 2.1% to "practically every case."
http://archsurg.jamanetwork.com/article.aspx?articleid=560162
Wednesday, September 4, 2013
"no primary data can be located, and no evidence has been found that the study described in the article was conducted"
The Australian understands a whistleblower lodged a complaint about the study, whose lead author was former UQ professor Bruce Murdoch, an internationally renowned expert on speech and language disorders.
UQ vice-chancellor Peter Hoj said the university had asked the European Journal of Neurology to retract the paper, and it had agreed, on the grounds "no primary data can be located, and no evidence has been found that the study described in the article was conducted".
Professor Murdoch had run the university's Centre for Neurogenic Communication Disorders Research. He is no longer employed at UQ and could not be contacted last night.
There has been no finding of misconduct against anybody. The investigation is continuing.
Mr Hoj said the retraction meant the global scientific community would be alerted that the study could not be relied on for further research.
The study, Treatment of articulatory dysfunction in Parkinson's disease using repetitive transcranial magnetic stimulation, was published online by the journal in October 2011. Professor Murdoch was lead author, with a researcher from the Speech Science Laboratory at the University of Hong Kong also cited.
http://www.theaustralian.com.au/higher-education/uq-pulls-study-on-lack-of-evidence/story-e6frgcjx-1226710106648
Subscribe to:
Posts (Atom)